The present paper aims to present the rivalry of global and regional capitalist powers for political, strategic, diplomatic, and economic influences in the contemporary Republic of Uzbekistan. The modern history and the contemporary political situation of the Uzbek state are the most important points of issue. After years of international isolation and etatist social and economic policy, under the new political leadership Uzbekistan implements economic transformation in the spirit of neo-liberal capitalism and it opens itself towards different forms of international cooperation and foreign investments. As a result, a Central Asian country which was isolated until recently gradually becomes an object of rivalry for economic and geopolitical influences. So far Uzbekistan has not become a satellite state or a quasi-colony of any of the powers. The multi-vector policy pursued by the political environment of Shavkat Mirziyoyev seems so far to successfully prevent the country being dominated by any outside center. The present article brings up the subject of relations of Uzbekistan with four great powers: the United States of America, the Russian Federation, the People’s Republic of China, and the Republic of Turkey.