The publication examines actual issues of interstate economic cooperation of the Shanghai Cooperation Organization member states in the framework of building new transport and communication routes. There was provided the analysis of the SCO normative legal documents in the terms of transport regulation, both road and rail, there were outlined the prospects and opportunities which emerge as a result of the signing of bilateral and multilateral agreements between the members of the Organization. The author describes the current situation of international transport communication routes and also reveals in details the initiatives proposed by Uzbekistan, pointing out his key role in the formation of new Eurasian transit corridors and arteries. Considering the issue of modern Eurasian interstate cooperation mechanisms’conjugation from an standpoint of creating and improving transport and logistics infrastructure, the author notes the possibility of implementing the initiatives of Russia and China on the SCO platform. Combination of such potential integration projects as the Eurasian Economic Union (EAEU) and the Silk Road Economic Belt (SREB) on the Shanghai Organization platform will create a new model of economic cooperation in the Russia-China-Central Asia triangle. The article also examines the measures taken by the SCO member states to build new and modernize existing road and rail routes on their own territories and on the territory of neighboring states. In the conclusion, it is pointed out that further positive shifts in the developing of the Shanghai Organization transport sector will largely depend on the ability of its participants to take a coordinated policy in the transport and logistics sector.